Implication of Additional Loci
نویسندگان
چکیده
Main Outcome Measures: Clinical diagnosis of LOAD. Results: Thestrongestoverall findingwasat chromosome 19q13.32,confirmingtheeffectof theapolipoproteinEgene on LOAD risk in the family-based and case-control analyses. However, single-nucleotide polymorphisms at the following loci were also statistically significant in 1 or more of the analyses performed: 7p22.2, 7p21.3, and 16q21 in the linkageanalyses;17q21.31and22q11.21inthefamily-based association analysis; and 7q31.1 and 22q12.3 in the casecontrolanalysis.Positiveassociationsat7q31.1and20q13.33 were also significant in the meta-analysis results in a publicly available database.
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تاریخ انتشار 2008